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. 2015 Oct 19;1:15044. doi: 10.1038/cddiscovery.2015.44

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Copyright © 2015 Cell Death Differentiation Association

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Model for H1047R-p110α-induced morphological change and increased cell motility in HCT116 cells. The H1047R mutation in p110α causes the downregulation of Bcl-2, which results an enhanced gelsolin-severing activity. This blocks actin polymerization, induces reorganization of actin cytoskeleton and increase filopodia formation. Moreover, the accumulation of PIP₃ and hyperactivity of Akt may modify the structure of the cytoskeleton by the different mechanisms.