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. 2016 Feb 29;2:16013. doi: 10.1038/cddiscovery.2016.13

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Copyright © 2016 Cell Death Differentiation Association

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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GADD45α stimulates apoptosis in ARPE-19 cells. (a) Overexpression of GADD45α in ARPE-19 cells resulted in a dose-dependent decrease in cell viability. Each point represents the mean value±S.E.M. (n=4, *P<0.05, ***P<0.001). (b) Overexpression of GADD45α significantly decreased cell viability, either with or without light damage. Each point represents the mean value±S.E.M. (n=4, ***P<0.001). (c) Knockdown of GADD45α in ARPE-19 cells using lentiviral delivery of shRNA. Results are given as mean value±S.E.M. (n=3, ***P<0.001). (d) Silencing GADD45α significantly reversed apoptosis in light-damaged RPE cells. Each value represents the mean value±S.E.M. (n=4, **P<0.01).