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. 2016 Jul 18;2:16053. doi: 10.1038/cddiscovery.2016.53

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Copyright © 2016 Official journal of the Cell Death Differentiation Association

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Embryological pathway for the development of the kidney, showing the critical differentiation milestones required for the formation of kidney tissue from stem cells. The genes serving as mileposts for directed differentiation of human pluripotent stem cells are outlined below each of the key stages of differentiation.