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. 2016 Jul 18;2:16053. doi: 10.1038/cddiscovery.2016.53

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Copyright © 2016 Official journal of the Cell Death Differentiation Association

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Transmission electron microscopy showing the presence of specific nephron cell types within the kidney organoids generated from human-induced pluripotent stem cells. A diagram of the presumed location of specific cell types along the nephron is shown centrally. (a) Distal tubular epithelium showing clear lumen and small apical microvilli (b, bʹ) Proximal epithelial tubules showing evidence (bʹ) of brush border (bb) and cell–cell tight junctions (tj) (c, cʹ) Forming glomerulus with evidence of tightly interdigitated podocytes (cʹ) with primary (fpf) and secondary (sfp) foot processes.