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. 2015 Nov 30;1:15058. doi: 10.1038/cddiscovery.2015.58

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Copyright © 2015 Cell Death Differentiation Association

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Cone size analysis in human patients with retinitis pigmentosa. (a–h) Representative adaptive optics scanning laser ophthalmoscopy (AO-SLO) images (a, c, e, g) and the spot diameter analysis (b, d, f, h) of the retina at 1.0 mm from the foveal center in a control subject (a, b) and retinitis pigmentosa (RP) patients with variable disease severity (c–h) The RP patients showed a decreased percentage of bright spots within 3.5–5.0 μm, and an increased percentage of large spots with ⩾6.0-μm diameter. The enlargement of bright spots was observed in a case with an intact ellipsoid zone (EZ) (d), as well as in cases with abnormal EZ (f) and absent EZ (h) at 1.0 mm eccentricity from the fovea. (i) Quantification of the percentage of bright spots with ⩾6.0-μm diameter in the control subjects (n=7) and RP patients (n=10). The RP patients had significantly higher percentages of enlarged bright spots compared with the controls (5.3±2.5 versus 0.6±0.6%) *P=0.0004.