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. 2016 May 16;2:16018. doi: 10.1038/cddiscovery.2016.18

Figure 1.

Figure 1

Xenon but not argon is protective against neuronal death induced by PDC in cortical cultures. (a) Survival rate of cortical neurons (MAP-2+ cells) in cultures exposed or not to PDC (3–100 μM) for 4 days under an atmosphere containing 75% N2, 75% Xe or 75% Ar. Error bars indicate mean±S.E.M. (n=9). **P<0.01,***P<0.001 relative to cultures receiving a same concentration of PDC under N2 atmosphere. (b) Survival of cortical neurons exposed to 30 μM PDC for 1 or 4 days in an atmosphere containing 75% N2 or 75% Xe. Error bars indicate mean ±S.E.M. (n=9). ***P<0.001 relative to control cultures maintained under N2 atmosphere and ### P<0.001 relative to age-matched PDC-treated cultures under N2 atmosphere. (c) Fluorescence digitized images illustrating the neuroprotective effects provided by a gas atmosphere containing 75% Xe (versus 75% N2) in cortical cultures exposed for 1 or 4 days to 30 μM of PDC. Scale bar 50 μm.