Figure 3.

Impact of xenon on the uptake and release of [³H]-D-aspartate in cortical cultures exposed to PDC. (a) [³H]-D-aspartate uptake measured in cortical cultures exposed acutely or not to PDC (30 μM) under an atmosphere containing 75% N₂ or 75% Xe, in the presence or not of memantine (10 μM). Error bars indicate mean±S.E.M. (n=6). ***P<0.001 relative to control cultures under N₂ atmosphere. (b) [³H]-D-aspartate released in cortical cultures exposed or not to PDC (30 μM) in an atmosphere containing 75% N₂ or 75% Xe, in the presence or not of memantine (10 μM). Error bars indicate mean±S.E.M. (n=9). ***P<0.001 relative to control cultures under N₂ atmosphere. Impact of an atmosphere containing 75% Xe on [³H]-D-aspartate release evoked by a depolarizing treatment with 4-aminopyridine (4-AP; 2.5 mM) and bicuculline (Bic; 50 μM). Error bars indicate mean±S.E.M. (n=9). **P<0.01, ***P<0.001 relative to control cultures maintained under N₂ atmosphere.