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. 2015 Oct 26;1:15017. doi: 10.1038/cddiscovery.2015.17

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Copyright © 2015 Cell Death Differentiation Association

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Electron microscopy of mitochondria and cytoplasm of curcumin-treated Huh-7 cells. (a) Electron micrographs illustrating time-dependent mitochondrial swelling in cells incubated with 25 μM curcumin for 1, 3 or 24 h. (b and c) Western blots of cytochrome c released in cells treated with different concentrations of curcumin, in the presence or absence of cyclosporine A. Triton X-100 treatment results in the release of the total cytochrome c available in cells. (c) Quantification of cytochrome c released in cells treated with different concentrations of curcumin and inhibition of this release by EGTA-AM or BAPTA-AM, which control intracellular calcium levels after curcumin addition. (d) Electron microscopy picture of autophagic vacuoles in cells treated with 25 μM curcumin for 24 h. AV, autophagic vacuoles; SM, swollen mitochondria; V, vacuole.