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. 2015 Oct 26;1:15017. doi: 10.1038/cddiscovery.2015.17

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Copyright © 2015 Cell Death Differentiation Association

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Caspase activity, regulation of caspase activity and PARP cleavage in curcumin-treated cells. (a) The activity of various caspases in cells treated with 25 μM curcumin. (b) Regulation of caspase-3/7, -9 and -8 activity by calcium chelators (BAPTA-AM or EGTA-AM; 25 μM), the mitochondrial calcium uniport inhibitor ruthenium red (5 μM) and a cathepsin inhibitor cocktail in cells treated with 25 μM curcumin for 24 h. (c) Western blot showing caspase-3 cleavage after treatment with 1, 5, 20 or 25 μM curcumin for 24 h. One lane shows samples treated with 25 μM curcumin after preincubation with 5 μM of ruthenium red. (d) Western blot showing PARP cleavage in cells treated with various concentrations of curcumin (from 0 to 80 μM).