Table 2. Laboratory parameters and blood pressure at baseline (T0), after 3 weeks (T1) and 6 weeks (T2) of low-protein diet.

Laboratory findings	T0	T1	T2	T0 versus T1, P	T0 versus T2, P	T1 versus T2, P
Creatinine (mg/dl)	3.3±0.5a	2.5±0.1a	2.3±0.2a	0.0001	<0.001	0.0002
eGFRb (ml/min)	23±1a	26±2a	29±2a	0.0003	0.0019	<0.0001
Azotemia (mg/dl)	83 (43–207)c	74 (35–216)c	66 (37–182)c	0.0026	0.0017	n.s.
Albumin (g/dl)	4.1±0.1a	4.1±0.1a	4.0±0.1a	n.s.	0.039	n.s.
Total protein (g/dl)	7.3±0.1a	6.9±0.1a	6.9±0.1a	<0.0001	<0.0001	n.s.
CRPb (mg/l)	1 (0–68)c	1 (0–66)c	2 (0–69)c	n.s.	0.0131	n.s.
Potassium (mEq/l)	4.6±0.1a	4.4±0.1a	4.5±0.1a	0.030	n.s.	n.s.
Phosphorus (mg/dl)	4.0 (3.0–5.8)c	3.8 (2.9–6.2)c	3.6 (2.5–5.5)c	n.s.	0.001	0.04
Sodium (mEq/l)	139±1a	138±1a	138±1a	n.s.	n.s.	n.s.
Calcium (mg/dl)	9.7 (7.8–11.0)c	9.6 (6.5–10.5)c	9.3 (7.4–10.6)c	0.0003	n.s.	0.0026
Total cholesterol (mg/dl)	177 (85–293)c	164 (91–335)c	164 (98–282)c	0.0025	n.s.	n.s.
LDL cholesterol (mg/dl)	104 (38–213)c	96 (41–238)c	102 (41–196)c	0.0118	n.s.	n.s.
HDL cholesterol (mg/dl)	51 (32–88)c	49 (30–90)c	47 (18–76)c	n.s.	n.s.	n.s.
Triglycerides (mg/dl)	133±7a	130±8a	144±10a	n.s.	n.s.	n.s.
Uric acid (mg/dl)	5.3 (1.5–12.1)c	5.6 (3.0–11.8)c	5.6 (3.3–6.9)c	n.s.	n.s.	n.s.
Albuminuria (mg/g)	51 (0–2237)c	33 (0–1799)c	22 (0–1656)c	<0.0001	<0.0001	0.03
Azoturia (mg/dl)	1088±98a	753±78a	603±67a	0.0001	<0.0001	0.01
Sodiuria (mmol/l)	61±5a	58±4a	61±4a	n.s.	n.s.	n.s.
Systolic blood pressure (mm Hg)	140 (105–224)c	130 (100–210)c	130 (100–185)c	0.0002	0.0006	n.s.

^aData are expressed as mean±S.E.M.

^beGFR, estimated Glomerular Filtration Rate; CRP, C-Reactive Protein. P<0.05 is considered statistically significant; n.s.=not significant.

^cData are expressed as median and range minimum-maximum.