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. 2015 Sep 7;1:15021. doi: 10.1038/cddiscovery.2015.21

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Copyright © 2015 Cell Death Differentiation Association

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Scheme of the effects occurring in SCs following 10 min EMF exposure. The SCs that were exposed to a high-frequency (50 Hz, 0.1 T) EMF change some biological processes, mainly increasing proliferation and migration; they become more responsive to chemoattractants (see Results). Contemporarily, SCs decrease their oncosuppressor characteristic, because their levels of the oncosuppressor Nf2/merlin resulted downregulated and differently distributed (see Results). By this way, SCs alter their differentiation program, becoming, in principle, pathologically relevant for schwannoma development.