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. 2016 May 9;2:16010. doi: 10.1038/cddiscovery.2016.10

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Copyright © 2016 Cell Death Differentiation Association

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Calcium imaging experiments in the native blood samples of clinically diagnosed AML patients. (a) Native white blood cells from AML patients showed an increase in their intracellular Ca²⁺ levels during isononyl alcohol application. (b) Representative calcium imaging with the application of 100 μM isononyl alcohol. (c) SQ-22536 abolished the isononyl alcohol-induced increase in intracellular Ca²⁺. (d) In absence of extracellular Ca²⁺ the isononyl alcohol-induced increase in intracellular Ca²⁺ was abolished. (e) Isononyl alcohol (100 μM) led to a significant increase in intracellular Ca²⁺ in ~35% of all AML cells. SQ-22536 and the extracellular Ca²⁺ chelator EGTA reduced the number of responding cells.