Table 1. The gene expression signatures of compounds most positively (mean score>0.7 and P<0.01) correlated with that of RRM2 siRNA.

CMAP drug	Function	Mean score	No of instances	Enrichment	P value	Specificity	Percent non-null
Phenoxybenzamine	Non-selective, irreversible alpha antagonist	0.892	4	0.986	0	0.0446	100
Doxorubicin	Topoisomerase II inhibitor	0.818	3	0.958	0.0001	0.0447	100
5248896	Unknown	0.812	2	0.974	0.00109	0	100
GW8510	CDK inhibitor	0.754	4	0.915	0.00004	0.0884	100
Trioxysalen	A furanocoumarin and a psoralen derivative	0.748	4	0.765	0.00581	0.0261	100
0175029-0000	CDK inhibitor	0.733	6	0.814	0.00008	0.0353	100
Daunorubicin	Topoisomerase II inhibitor	0.728	4	0.883	0.0002	0.0404	100
Thioguanosine	A purine analog showing antineoplastic activity	0.713	4	0.823	0.00167	0.0412	100
Ellipticine	Topoisomerase II inhibitor	0.711	4	0.844	0.00097	0.0608	100
Sulconazole	Antifungal medication of the imidazole class	0.708	4	0.738	0.00923	0.0375	100
Morantel	Anthelmintic for veterinary use	0.701	5	0.822	0.00038	0	100

Abbreviation: CDK, cyclin-dependent kinase. The results were ranked by their mean scores.