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. 2015 Nov 23;1:15038. doi: 10.1038/cddiscovery.2015.38

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Copyright © 2015 Cell Death Differentiation Association

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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JNK regulates CIDEA mediated actin cytoskeletal disruption. CIDEA overexpression alters the levels of phospho-VASP (a) and phospho-Cofilin (b) in glioma cell lines in a JNK dependent manner. A representative blot is shown from two independent experiments with identical results. Blots were re-probed with β-tubulin to establish loading control. (c) CIDEA overexpression affects actin cytoskeleton architecture in a JNK-dependent manner. Confocal imaging depicts that association between Cofilin (green, Alexa Fluor 488) and actin (red, rhodamine-phalloidin) observed in CIDEA overexpressing cells is reverted by JNK inhibition. Representative images from two independent experiments are shown for indicated conditions.