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Structural folds of core components of the bacterial and eukaryotic replisome
| Component | Bacterial (fold) | Eukaryote (fold) | Conserved in LUCA |
|---|---|---|---|
| Sliding clamp | beta (6 domain ring) | PCNA (6 domain ring) | yes |
| Clamp loader | tau complex (AAA+) | RFC (AAA+) | yes |
| Helicase | DnaB (RecA) | CMG (AAA+) | no |
| Primase | DnaG (Toprim) | Pol alpha/primase (DnaX) | no |
| DNA Polymerase | Pol III (C-family) | Pols epsilon/delta (B-family) | no |
