Table 3.
Mean anxiety, depression and test-related distress scores by randomization arm, APOE status, and time after APOE genotype disclosure.*
| ε4-negative | ε4-positive | p interact | |||||
|---|---|---|---|---|---|---|---|
| AD Only (n=87) | AD+ CAD (n=87) | Difference† (95% CI) | AD Only (n=51) | AD+ CAD (n=32) | Difference† (95% CI) | ||
| 12 month outcomes | |||||||
| BAI‡ | 2.8 | 3.6 | 0.9 (−0.2 to 2.0) | 4.8 | 3.1 | −1.7 (−3.5 to 0.1) | 0.048 |
| CES-D§ | 5.5 | 6.8 | 1.3 (−0.5 to 3.1) | 7.8 | 7.7 | −0.1 (−3.6 to 3.4) | 0.14 |
| IES|| | 2.1 | 2.7 | 0.6 (−1.1 to 2.2) | 7.1 | 2.3 | −4.8 (−8.6 to −1.0) | 0.031 |
| 6 month outcomes | |||||||
| BAI | 2.3 | 3.4 | 1.1 (0.1 to 2.0) | 3.8 | 2.0 | −1.8 (−3.2 to −0.4) | 0.004 |
| CES-D | 5.5 | 5.5 | 0.0 (−1.7 to 1.7) | 6.9 | 4.6 | −2.3 (−4.8 to 0.2) | 0.29 |
| IES | 2.4 | 3.0 | 0.7 (−1.3 to 2.6) | 7.0 | 4.7 | −2.3 (−5.9 to 1.4) | <0.001 |
| 6 week outcomes | |||||||
| BAI | 2.8 | 2.9 | 0.2 (−0.8 to 1.1) | 3.4 | 3.1 | −0.3 (−1.6 to 1.0) | 0.67 |
| CES-D | 5.9 | 5.6 | −0.3 (−2.1 to 1.5) | 5.3 | 4.6 | −0.7 (−2.7 to 1.3) | 0.60 |
| IES | 2.5 | 3.6 | 1.1 (−0.7 to 2.9) | 7.7 | 4.3 | −3.4 (−7.2 to 0.5) | 0.002 |
| Time-averaged outcomes | |||||||
| BAI | 2.6 | 3.3 | 0.7 (−0.1 to 1.5) | 4.0 | 2.7 | −1.3 (−2.3 to −0.2) | 0.006 |
| CES-D | 5.6 | 5.9 | 0.3 (−1.0 to 1.7) | 6.6 | 5.5 | −1.1 (−3.1 to 0.9) | 0.23 |
| IES | 2.3 | 3.1 | 0.8 (−0.7 to 2.3) | 7.2 | 3.6 | −3.6 (−7.0 to −0.2) | 0.005 |
Scores were estimated using generalized estimating equations with log link, gamma distribution and robust standard errors, adjusting for baseline values and the genetic counselor providing disclosure.
Difference refers to the mean scores among participants in the AD+CAD arms minus mean scores among participants in the AD-only arms.
Scores on the Beck Anxiety Inventory (BAI) range from 0 to 63, with higher scores indicating greater anxiety.
Scores on the Center for Epidemiological Studies Depression Scale (CES-D) range from 0 to 60, with higher scores indicating greater depression.
Scores on the Impact of Event Scale (IES) range from 0 to 75, with higher scores indicating greater distress.