Fig. 8.

In vivo ${}^{29}\mathrm{Si}$ MRI of ESTA-1 functionalized $2\mu \mathrm{m}$ silicon particles (100 mg; dissolved in 400 ml PBS) directly injected into the tumor volume of an orthotopic ovarian cancer mouse (HeyA8). Tumor periphery outlined in green. Single image taken 20 min postinjection, showing the silicon particles retain their enhanced signal while in the tumor volume. ${}^{29}\mathrm{Si}$ imaging scan (color): 90 deg RARE imaging sequence, TR/TE: $59.9/1.8\mathrm{ms}$, FOV: $64\times 64\mathrm{mm}$, resolution: 2 mm; single scan acquisition ($\text{scan time}\sim 60\mathrm{ms}$), processed with 35% threshold to filter background. Coregistered with ${}^1\mathrm{H}$ imaging scan (grayscale): 90 deg RARE imaging sequence, coronal plane, TR/TE: $1927/9.5\mathrm{ms}$, FOV: $64\times 64\mathrm{mm}$; resolution: 0.25 mm; four averages ($\text{scan time}\sim 4\min$).