Figure 1. Examples of covalent kinase inhibitors and their alkyne derivatives.

(A) Covalent kinase inhibitors that are currently used in the clinic. (B) A schematic representation of covalent probe composition that contains a scaffold (black) for kinase binding, an electrophile (red) for covalent labeling, and a terminal alkyne group (blue) as a “clickable” reporter. (C) Derivatives of covalent kinase inhibitors that contain a terminal alkyne group as a reporter.