. Author manuscript; available in PMC: 2017 Jun 1.

Published in final edited form as: Cognit Ther Res. 2016 Mar 24;40(3):426–440. doi: 10.1007/s10608-016-9772-2

Table 1. Original Five-Domain Research Domain Criteria (RDoC) Matrix.

Domain	Genes	Molecules	Cells	Circuits	Physiology	Behavior	Self-Report	Paradigms
Negative Valence Systems
Positive Valence Systems
Cognitive Systems
Social Processes
Arousal and Regulatory Systems