Table 2. Sample Depiction of Emotion Regulation as a Sixth RDoC Domain.

Domain	Genes	Molecules	Cells	Circuits	Physiology	Behavior	Self-report	Paradigms
Emotion Regulation	5-HTT1-2 COMT3 Oxytocin receptor gene4	Dopamine5 Serotonin6-9 Oxytocin10 Cortisol10-12	Microglia13 Cytokines14	Amygdala15-17 PFCs18-20,58 ACC21-23 Insula24	Skin conductance25,26, 29-30 Respiration26,28-30 Finger pulse amplitude25-26,28-30 Heart rate25-34 Somatic activity25,26,29-30 Blood pressure28-30 Facial EMG31,38 EEG35-38	Impromptu speeches39 CO2 challenge40 Behavioral observation/coding systems26,41-42	ERQ43 DERS44 CERQ45 ERI46 ERP-R47 EROS48 IERQ49 TAS-2056-57	Picture reappraisal50 Film clips26,51-52 Emotional Stroop Tasks53-55

Note. 5-HTT=serotonin transporter gene; COMT=catechol-O-methyltransferase gene; PFC=prefrontal cortices; ACC=anterior cingulate cortex; EMG=electromyography; EEG=electroencephalogram; ERQ=Emotion Regulation Questionnaire; DERS = Difficulties in Emotion Regulation Scale; CERQ = Cognitive Emotion Regulation Questionnaire; ERI = Emotion Regulation Interview; ERP-R=Emotion Regulation Profile-Revised; EROS=Emotion Regulation of Others and Self; IERQ=Interpersonal Emotion Regulation Questionnaire;

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²(Miu et al., 2013);

³(Nikolova, Davis, & Hariri, 2014);

⁴(Kim et al., 2011);

⁵(Salgado-Pineda et al., 2005);

⁶(Canli & Lesch, 2007);

⁷(Outhred et al., 2015);

⁸(Hariri & Holmes, 2006);

⁹(Crockett et al., 2008);

¹⁰(Quirin et al., 2011);

¹¹(Lam et al., 2009);

¹²(Poon et al., this issue);

¹³(Walker et al., 2013);

¹⁴(Miller et al., 2005);

¹⁵(Banks et al., 2007);

¹⁶(Etkin & Schatzberg, 2011);

¹⁷(Marusak et al., 2015);

¹⁸(Buhle et al., 2014);

¹⁹(Kohn et al., 2014);

²⁰(Ochsner et al., 2002);

²¹(Etkin, Egner, Peraza, Kandel, & Hirsch, 2006b);

²²(Etkin et al., 2010);

²³(Etkin & Wager, 2007);

²⁴(Phillips et al., 2003);

²⁵(Gross, 1998a);

²⁶(Gross & Levenson, 1993);

²⁷(Mauss et al., 2007);

²⁸(Dan-Glauser & Gross, 2015);

²⁹(Roberts et al., 2008);

³⁰(Giuliani et al., 2008);

³¹(vanOyen Witvliet, Knoll, Hinman, & DeYoung, 2010);

³²(Seeley et al., this issue);

³³(Williams et al., 2015);

³⁴(Yuan et al., 2015);

³⁵(MacNamara et al., this issue);

³⁶(Dennis, Malone, & Chen, 2009);

³⁷(Thiruchselvam, Blechert, Sheppes, Rydstrom, & Gross, 2011);

³⁸(Baur, Conzelmann, Wieser, & Pauli, 2015);

³⁹(Hofmann et al., 2009);

⁴⁰(Levitt et al., 2004);

⁴¹(Jahromi et al., 2012);

⁴²(Dixon-Gordon et al., this issue);

⁴³(Gross & John, 2003);

⁴⁴(Gratz & Roemer, 2004);

⁴⁵(Garnefski & Kraaij, 2007);

⁴⁶(Werner et al., 2011);

⁴⁷(Nelis, Quoidbach, Hansenne, & Mikolajczak, 2011);

⁴⁸(Niven et al., 2011);

⁴⁹(Hofmann et al., this issue);

⁵⁰(Sheppes et al., 2011);

⁵¹(Gross & Levenson, 1995);

⁵²(Rottenberg, Ray, & Gross, 2007);

⁵³(Mathews & MacLeod, 1985);

⁵⁴(Williams, Mathews, & MacLeod, 1996);

⁵⁵(Etkin et al., 2006b);

⁵⁶(Bagby, Parker, et al., 1994);

⁵⁷(Bagby, Taylor, et al., 1994);

⁵⁸(Ziv et al., 2013).