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letter
. 2016 Jul 18;12:1487–1492. doi: 10.3762/bjoc.12.145

Table 1.

Synthesis of imidazo[1,2-a]pyridine derivatives in indicated conditions [36].a

graphic file with name Beilstein_J_Org_Chem-12-1487-i001.jpg
Entry Solvent Acid Temperature Yield (%)
1 MeOH HClO4 rt 4
2 MeOH HClO4 reflux 11
3 MeCN HClO4 reflux –b
4 DMF HClO4 100 °C 10
5 EtOH HClO4 reflux 17
6 iPrOH HClO4 reflux 22
7 n-BuOH HClO4 reflux 30
8 iBuOH HClO4 reflux 21
9 t-BuOH HClO4 reflux 19
10 isopentyl alcohol HClO4 reflux 17
11 CF3CH2OH HClO4 reflux 13
12 n-BuOH PTSA reflux 20
13 n-BuOH HCl reflux –
14 n-BuOH AcOH reflux –
15 n-BuOH HClO4 reflux 42c

aConditions: 2a (1 mmol), 3a (1 mmol), 4a (1mmol), and acid HX (1 mmol) in 4 mL of solvent; b"–" indicates that the product was not obtained; cconditions: 2a (1.35 mmol), 3a (1 mmol), 4a (1.35 mmol), and acid HX (1 mmol) in 4 mL of solvent.