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. 2016 Aug 3;12:1647–1748. doi: 10.3762/bjoc.12.162

Table 16.

Acid-catalyzed Dakin oxidation of benzaldehydes 371a–c and acetophenones 371d–f by H2O2/H3BO3 in THF.

graphic file with name Beilstein_J_Org_Chem-12-1647-i075.jpg

Compound Carbonyl compound Reaction time, h Yield, % 372a–f

371a R1 = R2 = R3 = R4 = H 12 74
371b R1 = OH, R2 = R3 = R4 = H 7 80
371c R1 = R2 = R4 = H, R3 = OH 24 90
371d R1 = OH, R2 = R3 = H, R4 = Me 36 90
371e R1 = R2 = R3 = H, R4 = Me 24 63
371f R1 = R2 = H, R3 = NO2, R4 = Me 48 60