Skip to main content
. Author manuscript; available in PMC: 2016 Aug 10.
Published in final edited form as: Acta Neuropathol. 2012 Apr 25;123(6):787–805. doi: 10.1007/s00401-012-0987-3

Fig. 9. Mossy fiber dysfunction of basal transmission and short-term plasticity in mice expressing pro-aggregant or anti-aggregant hTau40.

Fig. 9

(a) Field excitatory postsynaptic potentials (fEPSP) evoked by stimulation of the mossy fiber (mf)-CA3 synapse in the hippocampus of controls (12 months), pro- and anti-ON (12 months ON), pro- and anti-ON/OFF (8 months ON + 4 months OFF) mice. (a1) Representative traces of input-output (I/O) recordings. (a2, a3) I/O curves of mf-fEPSP slopes. Synaptic responses in pro-ON mice are significantly decreased relative to controls (F = 34.497, p = 0.00011, repeated-measures ANOVA; a2), whereas there is no difference between anti-ON animals and controls (F = 0.911, p = 0.362; a3). (b) Paired pulse ratio (PPR) at 50ms inter stimulus interval (ISI) is significantly decreased in pro-ON mice compared to controls, pro-ON/OFF, anti-ON and anti-ON/OFF mice. Bars represent mean ± SEM, *p < 0.01; **p < 0.001, Student´s t-test. (c) Frequency facilitation (ff) is impaired in pro-ON mice compared to controls (F = 22.874, p = 0.00017, repeated-measures ANOVA, c1), anti-ON mice display diminished ff in comparison to anti-ON/OFF and controls (F = 25.795, p = 0.00017, c2). Potentiation of mf-fEPSP slopes at 1Hz is normalized to baseline values stimulated at 0.1Hz. Data represents mean ± SEM.