Table 3. CA3 mossy fiber plasticity.

CA3
	basal synaptic transmission		short-term plasticity				long-term plasticity
	I/O		PPR		FF		LTP
Pro-ON	↓	n = 10 p = 0.00011	↓	1.26 ± 0.047 n = 16	↓	207.76 ± 0.88% n = 11, p = 0.00017	↓	103.7 ± 0.85% n = 7, p = 0.0007
Pro-ON/OFF	-	n = 8	↓	1.51 ± 0.11 n = 17, p = 0.03	-	265.77 ± 9.6% n = 8	-	157.11 ± 0.96% n = 10
Anti-ON	-	n = 10	-	1.53 ± 0.097 n = 16, p = 0.66	↓	200.71 ± 1.28% n = 8, p = 0.00017	↓	134.67 ± 1.66% n = 8, p = 0.01870
Anti-ON/OFF	-	n = 6	-	1.608 ± 0.159 n = 11, p = 0.13	-	282.78 ± 1.68% n = 6	-	164.22 ± 1.37% n = 7
Control	-	n = 10	-	1.63 ± 0.12 n = 26, p = 0.006	-	288.02 ± 1.15% n = 8	-	176.25 ± 2.25% n = 8

Pro-ON: pro-aggregant 12 months ON; Pro-ON/OFF: pro-aggregant 8 months ON + 4 months OFF; Anti-ON: anti-aggregant 12 months ON; Anti-ON/OFF: anti-aggregant 8 months ON + 4 months OFF; Control (12 months); I/O: input/output curve; PPR: paired pulse ratio; FF: frequency facilitation; LTP: long term potentiation; ↓: decrease; -: no change. Data represents mean ± SEM. Statistical comparison of I/O, FF and LTP by repeated measures ANOVA; comparison of PPR by Student´s t-test.