Table 4.
Comorbidities and drug prescription of 434 patients with panel-confirmed heart failure, divided into those with reduced and preserved ejection fractiona
| HFrEF, % (n = 222) | HFpEF, % (n = 207) | P-value | |
|---|---|---|---|
| Mean age, years (SD) | 74.5 (11.3) | 79.9 (8.7) | <0.001 |
| Male sex | 57.2 | 37.7 | <0.001 |
|
| |||
| Comorbidities | |||
| Angina pectoris | 14.0 | 23.7 | 0.10 |
| Prior myocardial infarction | 47.7 | 16.4 | <0.001 |
| Atrial fibrillation | 35.6 | 62.3 | <0.001 |
| Stroke or TIA | 9.9 | 17.9 | 0.02 |
| COPD | 20.7 | 18.8 | 0.56 |
| Renal insufficiency (eGFR <30 mL/min/1.73 m2) | 9.9 | 9.7 | 0.75 |
| Hypertension | 45.5 | 64.7 | <0.001 |
| Diabetes mellitus | 33.3 | 31.4 | 0.67 |
|
| |||
| Drug prescriptions | |||
| Diuretics | 76.6 | 73.4 | 0.45 |
| ACE inhibitors or ARBs | 69.4 | 53.6 | <0.001 |
| Beta-blockers | 59.0 | 52.7 | 0.15 |
| MRAs | 31.5 | 24.6 | 0.13 |
| Digoxin | 15.3 | 26.6 | 0.01 |
a
Five (1.2%) patients with isolated right-sided HF are not included in this table.
ACE inhibitors = angiotensin-converting enzyme inhibitors. ARB = angiotensin receptor blocker. COPD = chronic obstructive pulmonary disease. eGFR = the calculated glomerular filtration rate according to the modification of diet in renal diseases (MDRD) formula. HFpEF = heart failure with a preserved ejection fraction. HFrEF = heart failure with a reduced ejection fraction. MRAs = mineralocorticoid receptor antagonists. SD = standard deviation. TIA = transient ischaemic attack.