Fig. 5.
Molecular model of the smAKAP-AKB-Phospho:PKA-RIαD/D interaction. Using the HADDOCK molecular modeling program, we obtained a best model wherein the phosphoserine is sticking out of the hydrophobic domain, which in turn allows hydrogen bonding with Gln26 and Lys 30 of PKA-RIα and Gln67 of smAKAP.