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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Biomaterials. 2015 Sep 4;73:1–11. doi: 10.1016/j.biomaterials.2015.09.001

Fig 4.

Fig 4

(a) Immunostaining for vWF (top row) and SMA (bottom row) following epicardial application of HA:Ser hydrogel(*). On d1 after epicardial hydrogel application, engorgement of blood vessels in epicardial region was observed. Greater numbers of arteries and capillaries (arrows) were visible in the epicardial region and at the periphery of hydrogels on d7, and more organized blood vessels were seen within the transplanted HA:Ser hydrogels on d14 compared to controls on d14. (b) Epicardial application of HA:Ser hydrogels stimulates angiogenesis, detected by immunostaining for von Williebrand factor (vWF) and smooth muscle actin (SMA) (n=10, p<0.001). (c) Schematics illustrating effects of cell suspension and cell encapsulation in HA:Ser hydrogels on cellular bioenergetics and viability.