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. Author manuscript; available in PMC: 2016 Aug 10.
Published in final edited form as: J Am Coll Cardiol. 2008 Nov 11;52(20):1652–1660. doi: 10.1016/j.jacc.2008.06.051

Figure 2. Effect of hNIS over-expression on cell viability, proliferation and function.

Figure 2

(a) There was no difference in viability and proliferation of NIS+ vs. non-transduced rCDCs. (b) Additional transduction with a lentiviral construct expressing firefly luciferase under the transcriptional control of a cardiac-specific promoter (NCX1, cardiac sodium-calcium exchanger) indicated no decrease in the cardiogenic potential of hNIS expressing cells compared to controls. (c-e) Angiogenesis and vascular tube formation assays. Representative images of Human Vascular Endothelial Cells as positive controls (c), non-transduced rCDCs (d), and rCDCs transduced with hNIS (e). The ability to form vascular structures was preserved after transduction with hNIS.