Fig. 2. In vulnerable tissues in healthy brains, the expression patterns of specific molecular chaperones and posttranslational modifiers predispose the aggregation of Aβ and tau.
Proteins known to promote Aβ and tau aggregation (termed “promoters”) are shown within ellipses, and proteins known to protect against it (termed “protectors”) are shown within rectangular boxes (table S4). Proteins whose roles in Aβ and tau aggregation are ambiguous in the literature are shown without frames and not considered in further analysis. ΔBI–III scores are color-coded according to the legend in the lower left corner. Error bars in the plot represent a 95% confidence interval on the mean (X symbol) calculated with 105 bootstrap cycles, ***P < 0.001 calculated with a two-tailed t test (49).