Fig. 5. Expression of different components of Aβ and tau homeostasis in specific brain cell types.

For different brain cell types, including neurons, astrocytes, microglia, and endothelial cells, we calculated the relative mRNA expression levels (40), as measured by the ${\mathit{E}}_{\mathit{g},\mathit{c}}^{’}$ score (see Methods), of genes corresponding to Aβ and tau, and the corresponding aggregation protectors and promoters. For each gene set in neurons, the significance of the difference with the expression distribution for all other brain cell types in combination was calculated using Mann-Whitney U test with Benjamini-Hochberg multiple hypothesis testing correction (50); ***P < 0.001 and *****P < 0.00001.