Table 1. Summary of de novo SNVs contributiona.

	ASD (n=192)	Control (n=258)	odds ratio (P)
Germline
All	9,774b	11,020	—
Coding	193 (1.98%)	136 (1.23%)	1.38 (5.0×10−3)
Predicted damaging
All	244	141	1.84 (8.0×10−9)
Coding	151 (61.9%)	97 (68.8%)	1.53 (1.3×10−3)c
Genic non-coding	55 (22.5%)	23 (16.3%)	2.59 (7.0×10−5)c
Non-genic non-coding	38 (15.6%)	21 (14.9%)	2.14 (4.3×10−3)d

Abbreviation: SNV, single nucleotide variant.

^aComparison was based on a logistic regression model with GC content correction (see Materials and methods).

^bSomatic mutations (n=613) were removed.

^cAll exonic and intronic variants as the universe.

^dAll non-exonic variants as the universe.