Table 1.
Summary of the AMPK-dependence and effects of agonists on cellular process
| mTOR signalling | Proliferation | Viability | Anchorage | Glycolysis | ATP-coupled | Oxygen consumption | Spare respiratory | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Effect | AMPK? | Effect | AMPK? | Effect | AMPK? | Effect | AMPK? | Effect | AMPK? | Effect | AMPK? | Effect | AMPK? | Effect | AMPK? | |
| Metformin | - | - |
|
No |
|
No | - | - |
|
No |
|
No |
|
No |
|
No |
| Phenformin |
|
Partial |
|
No |
|
No |
|
No |
|
No |
|
No |
|
No |
|
No |
| AICAR |
|
Yes |
|
No |
|
No | - | - |
|
No | - | - | - | - | - | - |
| 2DG |
|
Yes |
|
No |
|
No |
|
No |
|
No | - | - |
|
No |
|
No |
| Salicylate |
|
Partial |
|
No |
|
No |
|
No | - | - |
|
No | - | - | - | - |
| A-769662 |
|
Yes |
|
Yes | - | - | - | - | - | - | - | - |
|
Yes |
|
Yes |