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. 2016 Aug 10;11(8):e0160062. doi: 10.1371/journal.pone.0160062

Fig 4. ROC curve for direct Xpert CT, delta CT and percent closing relative to culture negativity at the same time point.

Fig 4

Assessment of direct Xpert Ct (A), delta Ct (B) and percent closing (C) values to predict the same-day culture negativity at day 7, week 4, week 8, and week 24. ROC curve results for direct Xpert Ct (optimal cut off approximately ≥30) at Day 7, AUC = 96.7 (95% CI 94.1, 99.3); at week 4, AUC = 91.2 (95% 85.8, 96.6); and week 8 AUC = 86.0 (95% 77.9, 94.2) and at week 24, AUC = 90.2 (95% 75.0, 100.0). ROC curve results for the delta Ct (optimal cut off values of approximately ≥ 10) at day 7, AUC = 97.5 (95% CI 94.5, 100.0); at week 4, AUC = 82.8 (95% 72.5, 93.1); at week 8, AUC = 75.2 (95%CI 64.8, 85.6); and at week 24, AUC = 82.2 (95%CI 67.9, 96.5). ROC curve results for the percent closing of the baseline Ct deficit at day 7, AUC = 96.6 (95% CI 94.0, 99.2); week 4, AUC = 91.6 (95%CI 86.2, 96.9); week 8, AUC = 79.8(70.3, 89.4); and at week 24, AUC = 86.0 (95%CI 71.3, 100.0).