Ictal onset zone is predicted by identifying which, if any, electrodes have
anomalously-high HFO rates. Results are shown per patient and per sampling rate (A) and
anti-aliasing filter position (B). Algorithm-identified ictal onset (IOZ) channels are
classified as either being fully within the resected volume (RV), not fully within the RV,
or in some cases, no channels were identified. Even though several patients’
answer change with different settings, there were never any predictions outside the RV,
which would have corresponded to a false positive prediction in these patients with class
I outcome. Note that because the algorithm was performed without any patient-specific
tuning, sometimes higher resolution does not improve the ability to predict IOZ due to
higher baseline HFO rates (e.g. UM-08).