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Thermal exchange studies of 40 μM 1a and 2a at 37 °C showing rapid exchange for 1a and slow exchange for 2a. (A) 1a in water, (B) 2a in water, (C) 1a in Opti-MEM, 1% FBS, and (D) 2a in Opti-MEM, 1% FBS. Insets show the change in absorbance fit to a one phase decay equation. Note: 2a undergoes incomplete conversion over the course of 15 hours.
