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Change in rectal temperature following nicotine, dFBr, PNU-120596, or LY 2087101 as a function of dose. Abscissa: Saline (Sal), vehicle consisting of propylene glycol, Tween 80, and saline (PGT) and dose in milligram per kilogram body weight. Ordinate: change in rectal temperature from pre-injection baseline expressed as °C.
