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. Author manuscript; available in PMC: 2017 Sep 5.
Published in final edited form as: Eur J Pharmacol. 2016 May 27;786:169–178. doi: 10.1016/j.ejphar.2016.05.032

Fig. 4.

Fig. 4

Change in rectal temperature as a function of nicotine dose administered alone and in combination with dFBr (10 and 32 mg/kg; left) or PNU-120596 (100 mg/kg; right). Abscissae: dose of positive allosteric modulator alone or vehicle (Veh) and dose of nicotine in milligram per kilogram bodyweight. Ordinates: change in rectal temperature from pre-injection baseline (i.e. immediately before time 0) expressed as °C. The same control nicotine dose-response function (circles) is plotted in the left and right panels.