Fig. 5.

The expected effects (open symbols) and observed effects (filled symbols) of nicotine in combination with either 32 mg/kg dFBr (left) or 100 mg/kg PNU-120596 (right). The expected effects were calculated as described in section 2.6 Data analyses. Abscissae: nicotine dose expressed as the sum of the experimentally administered dose and the dose of nicotine corresponding to the change in rectal temperature produced by 32 mg/kg dFBr (left) or 100 mg/kg PNU-120596 alone (right), as determined from non-linear regression of the experimentally derived nicotine dose-response function. Ordinates: change in rectal temperature from pre-injection baseline (i.e. immediately before time 0) expressed as °C.