Increased ROCK1 protein level in human AD brains. (a, b, and c) Immunoblots were performed using homogenates from control, asymptomatic AD (aAD), MCI due to AD, or AD brains. Case numbers correspond to information in Table 1. (c) Densitometry analysis indicated that ROCK1 is elevated in aAD, MCI, and AD, respectively, compared to controls. *p=0.0261, ***p=0.0002, **p=0.0016. Each case is expressed as an individual data point, and lines represent the mean.