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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: J Endocrinol. 2016 Jun 27;230(3):R115–R130. doi: 10.1530/JOE-16-0089

Figure 2.

Figure 2

Leptin alters the sensitivity of the skeleton to body weight changes. Total femur mass is strongly associated with body weight in 7-week-old female WT, partially leptin deficient ob/+, and leptin-deficient ob/ob mice fed a normal diet. ob/+ have near normal leptin levels due to increased fat mass and demonstrate an association between body weight and bone mass nearly identical to WT mice. In contrast, ob/ob mice require a much higher body weight to achieve a bone mass equivalent to WT. Please note that the slope of the regression lines is less than unity (0.49 for WT and ob/+ mice and 0.34 for ob/ob mice); increasing body weight by 50% in a WT mouse would be expected to lead to ~25% increase in bone mass. Reproduced, with permission, from Philbrick KA, Turner RT, Branscum AJ, Wong CP & Iwaniec UT (2015) Paradoxical effects of partial leptin deficiency on bone in growing female mice, The Anatomical Record 298 2018–2029. Copyright 2015 Wiley Periodicals, Inc.