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. Author manuscript; available in PMC: 2017 Feb 4.
Published in final edited form as: Nature. 2016 Aug 4;536(7614):86–90. doi: 10.1038/nature18935

Figure 1. The ‘don’t eat me’ ligand, CD47, is upregulated in atherosclerosis.

Figure 1

(a). Microarray expression profiling in two carotid endarterectomy (CEA) cohorts reveals that CD47 expression is significantly increased in human atherosclerotic plaque, relative to non-diseased vascular tissue (data displayed as Tukey boxplots, n=182 subjects). (b). Immunostaining identifies intense CD47 upregulation within the necrotic core of human atherosclerotic coronary artery lesions (left) and carotid plaques (right). (c). Taqman mRNA analysis confirms that vascular CD47 expression progressively increases in a mouse model of atherosclerosis (apoE−/− mice fed hi fat diet, grey), relative to control animals (C57BL/6 mice fed chow, white, n=4 mice/timepoint). (d). Immunohistochemistry staining with a biotin labeled antibody (brown) reveals that CD47 expression co-localizes with apoptotic tissue within murine atherosclerotic plaque. *** = P < 0.001, ** = P for trend < 0.03. Error bars represent the standard error of the mean (SEM).