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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Antiviral Res. 2016 Jun 17;132:186–195. doi: 10.1016/j.antiviral.2016.06.005

Figure 8. Exonuclease activity of the HBV RNaseH.

Figure 8

A. Time course for an ODN-directed RNA cleavage assay with MBP-HRHgtC employing the standard ODNs that bind internally in the DRF+ substrate. B. RNA stability during an RNaseH assay employing wildtype MBP-HRHgtC and its active site mutant MBP-HRHgtC(D702A/E731A) employing the standard ODNs that bind internally in the DRF+ substrate. C. Interpretation of the data. S, substrate; P1, product 1; P2, product 2; DE, MPB-HRHgtC(D702A/E731A); −, non-complementary control ODN; +, complementary ODN; grey line, ODN; black line, DRF+ RNA; dashed line, degraded RNA.