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In vivo seeding efficiency assay for human cells. Human cells exposed ex vivo (primed) to a pro-metastatic factor or a receptor blocking agent are subsequently injected i.v. into immunodeficient mice. Mice can be additionally irradiated with 360 cGy. The number of human cells can be detected in murine organs by FACS (after labelling cells with fluorochrome or transducing with GFP) or by detecting the level of human DNA in murine organs
