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. 2016 Jul 18;7(8):562–570. doi: 10.1007/s13238-016-0293-2

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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RNA recognition modes for ZIKV and DENV4 helicases. (A) Superposition of ZIKV (domains colored respectively) and DENV4 (white) apo-helicases. (B) Superposition of ZIKV (domains colored respectively and RNA in orange) and DENV4 (black and RNA in yellow) helicase-RNA complex. The distance between the sugar groups of nucleotide 1 in ZIKV and DENV4 helicases is marked in red. (C and D) show the conformation of subsite 1 of the ZIKV helicase-RNA complex (C) and the DENV4 helicase-RNA complex (D) in a 90° rotated view of (B). RNAs are shown in sticks and proteins are shown in ribbon with domains colored differently