Figure 5.

Comparison of protein-RNA interactions for ZIKV and DENV4 helicases. Left panels are for ZIKV helicase-RNA complex and right panels for DENV4. (A) The electrostatic surface representations showing the tunnel for RNA binding. Positive potentials are colored blue and the negative are colored red. The nucleic acids are shown in orange (ZIKV helicase) and yellow (DENV4 helicase). (B) Interactions in RNA binding tunnels. Proteins are shown in ribbon and colored according to domains. RNAs and interacting residues from the helicases are shown in sticks. Water molecules are shown in red spheres. (C) Detailed view for the protein-ssRNA interactions