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. 2016 Jul 29;7(8):571–585. doi: 10.1007/s13238-016-0295-0

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Ursolic acid inhibited proliferation and induced apoptosis in human CRC cell lines. (A) Ursolic acid inhibited proliferation of the four CRC cell lines in dose- and time-dependent manners as determined by MTT assay. (B) Ursolic acid induced apoptosis in four CRC cell lines as detected by TUNEL assay. Data represents the median values of triplicate experiments. (C–E) Ursolic acid induced apoptosis of SW620 as detected by AV/PI staining, mitochondrial membrane potential loss, and Hoechst 33342 staining. Quantitative analysis was performed for each method and the results were shown on the right, respectively. (F) Ursolic acid activated caspase cleavage in SW620 cells after 48 h treatment. (G) Ursolic acid inhibited the expression of Bcl-xL, Bcl-2, and survivin in SW620 cells

Ursolic acid inhibited proliferation and induced apoptosis in human CRC cell lines. (A) Ursolic acid inhibited proliferation of the four CRC cell lines in dose- and time-dependent manners as determined by MTT assay. (B) Ursolic acid induced apoptosis in four CRC cell lines as detected by TUNEL assay. Data represents the median values of triplicate experiments. (C–E) Ursolic acid induced apoptosis of SW620 as detected by AV/PI staining, mitochondrial membrane potential loss, and Hoechst 33342 staining. Quantitative analysis was performed for each method and the results were shown on the right, respectively. (F) Ursolic acid activated caspase cleavage in SW620 cells after 48 h treatment. (G) Ursolic acid inhibited the expression of Bcl-xL, Bcl-2, and survivin in SW620 cells