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. 2016 Jul 29;7(8):571–585. doi: 10.1007/s13238-016-0295-0

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Ursolic acid synergistically inhibited CRC cell growth with oxaliplatin and enhanced oxaliplatin-induced apoptosis in CRC cells. (A) Synergistic inhibitory effects of ursolic acid and oxaliplatin against four CRC cell lines as determined by MTT assay. (B) Quantification of TUNEL positive SW620 and RKO cells after treating with ursolic acid or oxaliplatin alone or in combination for 48 h. (C–G) SW620 cells were treated with ursolic acid or oxaliplatin alone or in combination for 48 h and cell apoptosis was detected by flow cytometry using five different methods: AV/PI staining, DNA content measurement, mitochondrial membrane potential loss, and Hoechst 33342 staining, and immunoblotting of caspase cleavage. Quantitative analysis was performed for each method and the results were shown on the right, respectively

Ursolic acid synergistically inhibited CRC cell growth with oxaliplatin and enhanced oxaliplatin-induced apoptosis in CRC cells. (A) Synergistic inhibitory effects of ursolic acid and oxaliplatin against four CRC cell lines as determined by MTT assay. (B) Quantification of TUNEL positive SW620 and RKO cells after treating with ursolic acid or oxaliplatin alone or in combination for 48 h. (C–G) SW620 cells were treated with ursolic acid or oxaliplatin alone or in combination for 48 h and cell apoptosis was detected by flow cytometry using five different methods: AV/PI staining, DNA content measurement, mitochondrial membrane potential loss, and Hoechst 33342 staining, and immunoblotting of caspase cleavage. Quantitative analysis was performed for each method and the results were shown on the right, respectively