Figure 5.

Ursolic acid in combination with oxaliplatin suppressed phosphorylation of ERK1/2, AKT, and NF-κB in tumor tissues and it potentially protected liver function of the mice. (A) Immunohistochemistry analysis of SW620 xenografts showed significantly decreased phosphorylation of ERK1/2, AKT, and IKKα in the combination group compared to either control or single oxaliplatin treated groups. Quantitative analysis was performed for each method and the results were shown, respectively. **, P < 0.01. (B) Western blot analysis showed that 10 or 20 mg/kg ursolic acid combined with 10 mg/kg oxaliplatin significantly inhibited the phosphorylation of ERK1/2, AKT, and IKKα in tumor tissues compared to either the control or the single oxaliplatin treated groups