Table 1. Summary of cases of metastatic signet ring cell carcinomas of unknown primary origin found on our review of the literature.
| Author, year | Age (years), gender | Chief complaint | Immunohistochemistry | Therapies attempted | Survival |
|---|---|---|---|---|---|
| O’Kane et al., 2014 | 70, male | Incidental finding on imaging after a motor vehicle accident | Positive for CK7 and CK20 | None | 3 months |
| Gregoire et al., 2014 | 70, female | Abdominal pain and weight loss | Positive for ER, PR and CK7 | Tamoxifen, letrozole, fulvestrant | 15 months |
| Unknown age, female | Abdominal pain | Positive for ER, PR and CK7 | Tamoxifen and letrozole | 37 months | |
| Kusakari et al., 2007 | 46, male | Incidental mass on chest imaging | Positive for CK7 | Cisplatin/irinotecan, S-1 | 24 months |
| Heidemann et al., 2002 | 71, female | Sanguineous discharge after defecation | Positive for pancytokeratin and EMA | 5-FU and folinic acid | 36 months |
| Shin et al., 2011 | 80, male | Back pain and jaundice, MAHA | Positive for CK20 | None | 3 weeks |
CK7, cytokeratin 7; CK20, cytokeratin 20; ER, estrogen receptor; PR, progesterone receptor; EMA, epithelial membrane antigen; 5-FU, 5-fluorouracil; MAHA, microangiopathic hemolytic anemia.