Figure 3.

Glyburide reduces anxiety-like behaviors associated with a HFD after 3 weeks of diet. HFD and LFD-mice were administered either saline or glyburide and examined after 4 h in an EZM. Time in the open (A) and closed arms (B) are presented. Similarly treated HFD- and LFD-mice were examined for locomotion (C), and post-behavior blood glucose (D). All results are expressed as mean ± SEM; n = 10–18, values without a common subscript or asterisk are different (a vs. b, p < 0.05) with (A,B) analyzed using one-way ANOVA and (C,D) using two-way ANOVA.